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1kuh

From Proteopedia

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[[Image:1kuh.gif|left|200px]]
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{{Seed}}
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[[Image:1kuh.png|left|200px]]
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{{STRUCTURE_1kuh| PDB=1kuh | SCENE= }}
{{STRUCTURE_1kuh| PDB=1kuh | SCENE= }}
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'''ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS'''
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===ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS===
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==Overview==
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A zinc endoprotease produced by Streptomyces caespitosus (ScNP) specifically hydrolyzes the peptide bond at the imino side of aromatic residues and is the smallest protease found to date. Although ScNP carries the zinc-binding sequence HEXXH, its primary structure of 132 amino acid residues differs from those of other known zinc metalloendoproteases. X-ray structural analysis of ScNP at 1.6 A resolution revealed that despite a lack of sequence homology, the common topological feature of main-chain folding and a beta-turn containing methionine, which is a feature of the zinc metalloendoprotease superfamily of metzincins, is conserved in ScNP. The zinc atom of ScNP is tetrahedrally ligated by the two histidines in the HEXXH sequence, an aspartate residue and a water molecule. Thus, ScNP represents a novel subfamily of metzincins with a HEXXHXXGXXD zinc-binding sequence. A plausible substrate recognition pocket to which aromatic residues bind is located near the catalytic zinc ion.
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The line below this paragraph, {{ABSTRACT_PUBMED_9089404}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9089404 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9089404}}
==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Metalloproteinase]]
[[Category: Metalloproteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:10:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:01:29 2008''

Revision as of 08:01, 2 July 2008

Image:1kuh.png

Template:STRUCTURE 1kuh

ZINC PROTEASE FROM STREPTOMYCES CAESPITOSUS

Template:ABSTRACT PUBMED 9089404

About this Structure

1KUH is a Single protein structure of sequence from Streptomyces caespitosus. Full crystallographic information is available from OCA.

Reference

Structure of the zinc endoprotease from Streptomyces caespitosus., Kurisu G, Kinoshita T, Sugimoto A, Nagara A, Kai Y, Kasai N, Harada S, J Biochem. 1997 Feb;121(2):304-8. PMID:9089404

Page seeded by OCA on Wed Jul 2 11:01:29 2008

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