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1kxg

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[[Image:1kxg.gif|left|200px]]
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{{STRUCTURE_1kxg| PDB=1kxg | SCENE= }}
{{STRUCTURE_1kxg| PDB=1kxg | SCENE= }}
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''
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===The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.===
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==Overview==
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B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.
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(as it appears on PubMed at http://www.pubmed.gov), where 11862220 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11862220}}
==About this Structure==
==About this Structure==
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[[Category: Tnf superfamily]]
[[Category: Tnf superfamily]]
[[Category: Ztnf4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:17:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:13:37 2008''

Revision as of 08:13, 2 July 2008

Image:1kxg.png

Template:STRUCTURE 1kxg

The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.

Template:ABSTRACT PUBMED 11862220

About this Structure

1KXG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220

Page seeded by OCA on Wed Jul 2 11:13:37 2008

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