1l0x

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[[Image:1l0x.gif|left|200px]]
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{{Seed}}
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[[Image:1l0x.png|left|200px]]
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{{STRUCTURE_1l0x| PDB=1l0x | SCENE= }}
{{STRUCTURE_1l0x| PDB=1l0x | SCENE= }}
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'''TCR beta chain complexed with streptococcal superantigen SpeA'''
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===TCR beta chain complexed with streptococcal superantigen SpeA===
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==Overview==
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Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation.
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The line below this paragraph, {{ABSTRACT_PUBMED_12015151}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12015151 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12015151}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Tcr]]
[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:25:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:27:22 2008''

Revision as of 08:27, 2 July 2008

Image:1l0x.png

Template:STRUCTURE 1l0x

TCR beta chain complexed with streptococcal superantigen SpeA

Template:ABSTRACT PUBMED 12015151

About this Structure

1L0X is a Protein complex structure of sequences from Mus musculus and Streptococcus pyogenes. Full crystallographic information is available from OCA.

Reference

Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes., Sundberg EJ, Li H, Llera AS, McCormick JK, Tormo J, Schlievert PM, Karjalainen K, Mariuzza RA, Structure. 2002 May;10(5):687-99. PMID:12015151

Page seeded by OCA on Wed Jul 2 11:27:22 2008

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