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1l1c

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{{STRUCTURE_1l1c| PDB=1l1c | SCENE= }}
{{STRUCTURE_1l1c| PDB=1l1c | SCENE= }}
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'''Structure of the LicT Bacterial Antiterminator Protein in Complex with its RNA Target'''
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===Structure of the LicT Bacterial Antiterminator Protein in Complex with its RNA Target===
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==Overview==
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LicT is a bacterial regulatory protein able to prevent the premature arrest of transcription. When activated, LicT binds to a 29 base RNA hairpin overlapping a terminator located in the 5' mRNA leader region of the target genes. We have determined the solution structure of the LicT RNA-binding domain (CAT) in complex with its ribonucleic antiterminator (RAT) target by NMR spectroscopy (PDB 1L1C). CAT is a beta-stranded homodimer that undergoes no important conformational changes upon complex formation. It interacts, through mostly hydrophobic and stacking interactions, with the distorted minor groove of the hairpin stem that is interrupted by two asymmetric internal loops. Although different in sequence, these loops share sufficient structural analogy to be recognized similarly by symmetry-related elements of the protein dimer, leading to a quasi- symmetric structure reminiscent of that observed with dimeric transcription regulators bound to palindromic DNA. Sequence analysis suggests that this RNA- binding mode, where the RAT strands are clamped by the CAT dimer, is conserved in homologous systems.
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{{ABSTRACT_PUBMED_11953318}}
==About this Structure==
==About this Structure==
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1L1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1C OCA].
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1L1C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L1C OCA].
==Reference==
==Reference==
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[[Category: Protein rna complex]]
[[Category: Protein rna complex]]
[[Category: Rna hairpin]]
[[Category: Rna hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:25:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:28:42 2008''

Revision as of 08:28, 2 July 2008

Image:1l1c.png

Template:STRUCTURE 1l1c

Structure of the LicT Bacterial Antiterminator Protein in Complex with its RNA Target

Template:ABSTRACT PUBMED 11953318

About this Structure

1L1C is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

Solution structure of the LicT-RNA antitermination complex: CAT clamping RAT., Yang Y, Declerck N, Manival X, Aymerich S, Kochoyan M, EMBO J. 2002 Apr 15;21(8):1987-97. PMID:11953318

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