1l2q

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{{STRUCTURE_1l2q| PDB=1l2q | SCENE= }}
{{STRUCTURE_1l2q| PDB=1l2q | SCENE= }}
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'''Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)'''
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===Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)===
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==Overview==
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Genes encoding methanogenic methylamine methyltransferases all contain an in-frame amber (UAG) codon that is read through during translation. We have identified the UAG-encoded residue in a 1.55 angstrom resolution structure of the Methanosarcina barkeri monomethylamine methyltransferase (MtmB). This structure reveals a homohexamer comprised of individual subunits with a TIM barrel fold. The electron density for the UAG-encoded residue is distinct from any of the 21 natural amino acids. Instead it appears consistent with a lysine in amide-linkage to (4R,5R)-4-substituted-pyrroline-5-carboxylate. We suggest that this amino acid be named l-pyrrolysine.
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(as it appears on PubMed at http://www.pubmed.gov), where 12029132 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12029132}}
==About this Structure==
==About this Structure==
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[[Category: Krzycki, J A.]]
[[Category: Krzycki, J A.]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:28:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:34:16 2008''

Revision as of 08:34, 2 July 2008

Image:1l2q.png

Template:STRUCTURE 1l2q

Crystal Structure of the Methanosarcina barkeri Monomethylamine Methyltransferase (MtmB)

Template:ABSTRACT PUBMED 12029132

About this Structure

1L2Q is a Single protein structure of sequence from Methanosarcina barkeri. Full crystallographic information is available from OCA.

Reference

A new UAG-encoded residue in the structure of a methanogen methyltransferase., Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK, Science. 2002 May 24;296(5572):1462-6. PMID:12029132

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