1l6m

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{{STRUCTURE_1l6m| PDB=1l6m | SCENE= }}
{{STRUCTURE_1l6m| PDB=1l6m | SCENE= }}
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'''Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition'''
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===Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition===
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==Overview==
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First identified as a neutrophil granule component, neutrophil gelatinase-associated lipocalin (NGAL; also called human neutrophil lipocalin, 24p3, uterocalin, or neu-related lipocalin) is a member of the lipocalin family of binding proteins. Putative NGAL ligands, including neutrophil chemotactic agents such as N-formylated tripeptides, have all been refuted by recent biochemical and structural results. NGAL has subsequently been implicated in diverse cellular processes, but without a characterized ligand, the molecular basis of these functions remained mysterious. Here we report that NGAL tightly binds bacterial catecholate-type ferric siderophores through a cyclically permuted, hybrid electrostatic/cation-pi interaction and is a potent bacteriostatic agent in iron-limiting conditions. We therefore propose that NGAL participates in the antibacterial iron depletion strategy of the innate immune system.
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The line below this paragraph, {{ABSTRACT_PUBMED_12453412}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12453412 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12453412}}
==About this Structure==
==About this Structure==
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[[Category: Lipocalin]]
[[Category: Lipocalin]]
[[Category: Siderophore]]
[[Category: Siderophore]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:35:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 11:48:52 2008''

Revision as of 08:48, 2 July 2008

Image:1l6m.png

Template:STRUCTURE 1l6m

Neutrophil Gelatinase-associated Lipocalin is a Novel Bacteriostatic Agent that Interferes with Siderophore-mediated Iron Acquisition

Template:ABSTRACT PUBMED 12453412

About this Structure

1L6M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition., Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK, Mol Cell. 2002 Nov;10(5):1033-43. PMID:12453412

Page seeded by OCA on Wed Jul 2 11:48:52 2008

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