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1l9m

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[[Image:1l9m.gif|left|200px]]
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[[Image:1l9m.png|left|200px]]
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{{STRUCTURE_1l9m| PDB=1l9m | SCENE= }}
{{STRUCTURE_1l9m| PDB=1l9m | SCENE= }}
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'''Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation'''
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===Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation===
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==Overview==
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Transglutaminase (TGase) enzymes catalyze the formation of covalent cross-links between protein-bound glutamines and lysines in a calcium-dependent manner, but the role of Ca(2+) ions remains unclear. The TGase 3 isoform is widely expressed and is important for epithelial barrier formation. It is a zymogen, requiring proteolysis for activity. We have solved the three-dimensional structures of the zymogen and the activated forms at 2.2 and 2.1 A resolution, respectively, and examined the role of Ca(2+) ions. The zymogen binds one ion tightly that cannot be exchanged. Upon proteolysis, the enzyme exothermally acquires two more Ca(2+) ions that activate the enzyme, are exchangeable and are functionally replaceable by other lanthanide trivalent cations. Binding of a Ca(2+) ion at one of these sites opens a channel which exposes the key Trp236 and Trp327 residues that control substrate access to the active site. Together, these biochemical and structural data reveal for the first time in a TGase enzyme that Ca(2+) ions induce structural changes which at least in part dictate activity and, moreover, may confer substrate specificity.
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The line below this paragraph, {{ABSTRACT_PUBMED_11980702}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 11980702 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11980702}}
==About this Structure==
==About this Structure==
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[[Category: Transglutaminase]]
[[Category: Transglutaminase]]
[[Category: X-ray structure]]
[[Category: X-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:42:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:02:21 2008''

Revision as of 09:02, 2 July 2008

Image:1l9m.png

Template:STRUCTURE 1l9m

Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions change structure for activation

Template:ABSTRACT PUBMED 11980702

About this Structure

1L9M is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation., Ahvazi B, Kim HC, Kee SH, Nemes Z, Steinert PM, EMBO J. 2002 May 1;21(9):2055-67. PMID:11980702

Page seeded by OCA on Wed Jul 2 12:02:21 2008

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