1ldp

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{{STRUCTURE_1ldp| PDB=1ldp | SCENE= }}
{{STRUCTURE_1ldp| PDB=1ldp | SCENE= }}
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'''CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES'''
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===CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES===
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==Overview==
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MHC class I H-2Ld complexed with peptide QL9 (or p2Ca) is a high-affinity alloantigen for the 2C TCR. We used the crystal structure of H-2Ld with a mixture of bound peptides at 3.1 A to construct a model of the allogeneic 2C-Ld/QL9 complex for comparison with the syngeneic 2C-Kb/dEV8 structure. A prominent ridge on the floor of the Ld peptide-binding groove, not present in Kb, creates a C-terminal bulge in Ld peptides that greatly increases interactions with the 2C beta-chain. Furthermore, weak electrostatic complementarity between Asp77 on the alpha1 helix of Kb and 2C is enhanced in the allogeneic complex by closer proximity of QL9 peptide residue AspP8 to the 2C HV4 loop.
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(as it appears on PubMed at http://www.pubmed.gov), where 9620676 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9620676}}
==About this Structure==
==About this Structure==
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[[Category: Major histocompatibility complex]]
[[Category: Major histocompatibility complex]]
[[Category: Peptide antigen]]
[[Category: Peptide antigen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:49:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 12:44:37 2008''

Revision as of 09:45, 2 July 2008

Image:1ldp.png

Template:STRUCTURE 1ldp

CRYSTAL STRUCTURE OF MURINE MHC CLASS I H-2LD WITH A MIXTURE OF BOUND PEPTIDES

Template:ABSTRACT PUBMED 9620676

About this Structure

1LDP is a Protein complex structure of sequences from Drosophila melanogaster and Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes., Speir JA, Garcia KC, Brunmark A, Degano M, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 May;8(5):553-62. PMID:9620676

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