1ln6

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{{STRUCTURE_1ln6| PDB=1ln6 | SCENE= }}
{{STRUCTURE_1ln6| PDB=1ln6 | SCENE= }}
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'''STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)'''
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===STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)===
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==Overview==
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The structural changes that accompany activation of a G-protein coupled receptor (GPCR) are not well understood. To better understand the activation of rhodopsin, the GPCR responsible for visual transduction, we report studies on the three-dimensional structure for the activated state of this receptor, metarhodopsin II. Differences between the three-dimensional structure of ground state rhodopsin and metarhodopsin II, particularly in the cytoplasmic face of the receptor, suggest how the receptor is activated to couple with transducin. In particular, activation opens a groove on the surface of the receptor that could bind the N-terminal helix of the G protein, transducin alpha.
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The line below this paragraph, {{ABSTRACT_PUBMED_12044163}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12044163 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12044163}}
==About this Structure==
==About this Structure==
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1LN6 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LN6 OCA].
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1LN6 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LN6 OCA].
==Reference==
==Reference==
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[[Category: Metarhodopsin ii]]
[[Category: Metarhodopsin ii]]
[[Category: Rhodopsin]]
[[Category: Rhodopsin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:05:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:29:06 2008''

Revision as of 18:29, 2 July 2008

Image:1ln6.png

Template:STRUCTURE 1ln6

STRUCTURE OF BOVINE RHODOPSIN (Metarhodopsin II)

Template:ABSTRACT PUBMED 12044163

About this Structure

1LN6 is a Single protein structure. Full experimental information is available from OCA.

Reference

Structural studies of metarhodopsin II, the activated form of the G-protein coupled receptor, rhodopsin., Choi G, Landin J, Galan JF, Birge RR, Albert AD, Yeagle PL, Biochemistry. 2002 Jun 11;41(23):7318-24. PMID:12044163

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