1lpe

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[[Image:1lpe.jpg|left|200px]]
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{{Seed}}
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[[Image:1lpe.png|left|200px]]
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{{STRUCTURE_1lpe| PDB=1lpe | SCENE= }}
{{STRUCTURE_1lpe| PDB=1lpe | SCENE= }}
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'''THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E'''
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===THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E===
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==Overview==
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Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the low-density lipoprotein (LDL) receptor. The three-dimensional structure of the LDL receptor-binding domain of apoE has been determined at 2.5 angstrom resolution by x-ray crystallography. The protein forms an unusually elongated (65 angstroms) four-helix bundle, with the helices apparently stabilized by a tightly packed hydrophobic core that includes leucine zipper-type interactions and by numerous salt bridges on the mostly charged surface. Basic amino acids important for LDL receptor binding are clustered into a surface patch on one long helix. This structure provides the basis for understanding the behavior of naturally occurring mutants that can lead to atherosclerosis.
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The line below this paragraph, {{ABSTRACT_PUBMED_2063194}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 2063194 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2063194}}
==About this Structure==
==About this Structure==
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[[Category: Wilson, C.]]
[[Category: Wilson, C.]]
[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:08:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 21:42:49 2008''

Revision as of 18:42, 2 July 2008

Image:1lpe.png

Template:STRUCTURE 1lpe

THREE-DIMENSIONAL STRUCTURE OF THE LDL RECEPTOR-BINDING DOMAIN OF HUMAN APOLIPOPROTEIN E

Template:ABSTRACT PUBMED 2063194

About this Structure

1LPE is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E., Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA, Science. 1991 Jun 28;252(5014):1817-22. PMID:2063194

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