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1lsl

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{{STRUCTURE_1lsl| PDB=1lsl | SCENE= }}
{{STRUCTURE_1lsl| PDB=1lsl | SCENE= }}
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'''Crystal Structure of the Thrombospondin-1 Type 1 Repeats'''
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===Crystal Structure of the Thrombospondin-1 Type 1 Repeats===
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==Overview==
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Thrombospondin-1 (TSP-1) contains three type 1 repeats (TSRs), which mediate cell attachment, glycosaminoglycan binding, inhibition of angiogenesis, activation of TGFbeta, and inhibition of matrix metalloproteinases. The crystal structure of the TSRs reported in this article reveals a novel, antiparallel, three-stranded fold that consists of alternating stacked layers of tryptophan and arginine residues from respective strands, capped by disulfide bonds on each end. The front face of the TSR contains a right-handed spiral, positively charged groove that might be the "recognition" face, mediating interactions with various ligands. This is the first high-resolution crystal structure of a TSR domain that provides a prototypic architecture for structural and functional exploration of the diverse members of the TSR superfamily.
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(as it appears on PubMed at http://www.pubmed.gov), where 12391027 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12391027}}
==About this Structure==
==About this Structure==
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[[Category: Tsp-1]]
[[Category: Tsp-1]]
[[Category: Tsr]]
[[Category: Tsr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:14:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:02:50 2008''

Revision as of 19:02, 2 July 2008

Image:1lsl.png

Template:STRUCTURE 1lsl

Crystal Structure of the Thrombospondin-1 Type 1 Repeats

Template:ABSTRACT PUBMED 12391027

About this Structure

1LSL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the TSP-1 type 1 repeats: a novel layered fold and its biological implication., Tan K, Duquette M, Liu JH, Dong Y, Zhang R, Joachimiak A, Lawler J, Wang JH, J Cell Biol. 2002 Oct 28;159(2):373-82. Epub 2002 Oct 21. PMID:12391027

Page seeded by OCA on Wed Jul 2 22:02:50 2008

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