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1ltq

From Proteopedia

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[[Image:1ltq.gif|left|200px]]
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{{STRUCTURE_1ltq| PDB=1ltq | SCENE= }}
{{STRUCTURE_1ltq| PDB=1ltq | SCENE= }}
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'''CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE'''
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===CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE===
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==Overview==
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T4 phage polynucleotide kinase (PNK) was identified over 35 years ago and has become a staple reagent for molecular biologists. The enzyme displays 5'-hydroxyl kinase, 3'-phosphatase, and 2',3'-cyclic phosphodiesterase activities against a wide range of substrates. These activities modify the ends of nicked tRNA generated by a bacterial response to infection and facilitate repair by T4 RNA ligase. DNA repair enzymes that share conserved motifs with PNK have been identified in eukaryotes. PNK contains two functionally distinct structural domains and forms a homotetramer. The C-terminal phosphatase domain is homologous to the L-2-haloacid dehalogenase family and the N-terminal kinase domain is homologous to adenylate kinase. The active sites have been characterized through structural homology analyses and visualization of bound substrate.
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(as it appears on PubMed at http://www.pubmed.gov), where 12220496 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12220496}}
==About this Structure==
==About this Structure==
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[[Category: P-loop]]
[[Category: P-loop]]
[[Category: Phosphatase]]
[[Category: Phosphatase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:12:37 2008''

Revision as of 19:12, 2 July 2008

Image:1ltq.png

Template:STRUCTURE 1ltq

CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE

Template:ABSTRACT PUBMED 12220496

About this Structure

1LTQ is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.

Reference

Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase., Galburt EA, Pelletier J, Wilson G, Stoddard BL, Structure. 2002 Sep;10(9):1249-60. PMID:12220496

Page seeded by OCA on Wed Jul 2 22:12:37 2008

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