1luj

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[[Image:1luj.gif|left|200px]]
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{{Seed}}
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[[Image:1luj.png|left|200px]]
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{{STRUCTURE_1luj| PDB=1luj | SCENE= }}
{{STRUCTURE_1luj| PDB=1luj | SCENE= }}
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'''Crystal Structure of the Beta-catenin/ICAT Complex'''
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===Crystal Structure of the Beta-catenin/ICAT Complex===
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==Overview==
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Beta-catenin is a multifunctional protein involved in both cell adhesion and transcriptional activation. Transcription mediated by the beta-catenin/Tcf complex is involved in embryological development and is upregulated in various cancers. We have determined the crystal structure at 2.5 A resolution of a complex between beta-catenin and ICAT, a protein that prevents the interaction between beta-catenin and Tcf/Lef family transcription factors. ICAT contains a 3-helix bundle that binds armadillo repeats 10-12 and a C-terminal tail that, similar to Tcf and E-cadherin, binds in the groove formed by armadillo repeats 5-9 of beta-catenin. We show that ICAT selectively inhibits beta-catenin/Tcf binding in vivo, without disrupting beta-catenin/cadherin interactions. Thus, it should be possible to design cancer therapeutics that inhibit beta-catenin-mediated transcriptional activation without interfering with cell adhesion.
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The line below this paragraph, {{ABSTRACT_PUBMED_12408824}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12408824 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12408824}}
==About this Structure==
==About this Structure==
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Wnt pathway]]
[[Category: Wnt pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:18:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:18:39 2008''

Revision as of 19:18, 2 July 2008

Image:1luj.png

Template:STRUCTURE 1luj

Crystal Structure of the Beta-catenin/ICAT Complex

Template:ABSTRACT PUBMED 12408824

About this Structure

1LUJ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT., Graham TA, Clements WK, Kimelman D, Xu W, Mol Cell. 2002 Sep;10(3):563-71. PMID:12408824

Page seeded by OCA on Wed Jul 2 22:18:39 2008

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