1lum

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{{STRUCTURE_1lum| PDB=1lum | SCENE= }}
{{STRUCTURE_1lum| PDB=1lum | SCENE= }}
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'''NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures'''
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===NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures===
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==Overview==
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Interleukin-2 tyrosine kinase (Itk) is a T cell-specific kinase required for a proper immune response following T cell receptor engagement. In addition to the kinase domain, Itk is composed of several noncatalytic regulatory domains, including a Src homology 2 (SH2) domain that contains a conformationally heterogeneous Pro residue. Cis-trans isomerization of a single prolyl imide bond within the SH2 domain mediates conformer-specific ligand recognition that may have functional implications in T cell signaling. To better understand the mechanism by which a proline switch regulates ligand binding, we have used NMR spectroscopy to determine two structures of Itk SH2 corresponding to the cis and trans imide bond-containing conformers. The structures indicate that the heterogeneous Pro residue acts as a hinge that modulates ligand recognition by controlling the relative orientation of protein-binding surfaces.
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(as it appears on PubMed at http://www.pubmed.gov), where 12402030 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12402030}}
==About this Structure==
==About this Structure==
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1LUM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUM OCA].
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1LUM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LUM OCA].
==Reference==
==Reference==
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[[Category: T-cell specific kinase]]
[[Category: T-cell specific kinase]]
[[Category: Tsk]]
[[Category: Tsk]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:18:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:19:16 2008''

Revision as of 19:19, 2 July 2008

Image:1lum.png

Template:STRUCTURE 1lum

NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures

Template:ABSTRACT PUBMED 12402030

About this Structure

1LUM is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Structural characterization of a proline-driven conformational switch within the Itk SH2 domain., Mallis RJ, Brazin KN, Fulton DB, Andreotti AH, Nat Struct Biol. 2002 Dec;9(12):900-5. PMID:12402030

Page seeded by OCA on Wed Jul 2 22:19:16 2008

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