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1lww

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[[Image:1lww.gif|left|200px]]
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{{STRUCTURE_1lww| PDB=1lww | SCENE= }}
{{STRUCTURE_1lww| PDB=1lww | SCENE= }}
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'''Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine'''
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===Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine===
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==Overview==
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Most spontaneous damage to bases in DNA is corrected through the action of the base-excision DNA repair pathway. Base excision repair is initiated by DNA glycosylases, lesion-specific enzymes that intercept aberrant bases in DNA and catalyze their excision. How such proteins accomplish the feat of catalyzing no fewer than five sequential reaction steps using a single active site has been unknown. To help answer this, we report the structure of a trapped catalytic intermediate in DNA repair by human 8-oxoguanine DNA glycosylase. This structure and supporting biochemical results reveal that the enzyme sequesters the excised lesion base and exploits it as a cofactor to participate in catalysis. To our knowledge, the present example represents the first documented case of product-assisted catalysis in an enzyme-catalyzed reaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 12592398 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12592398}}
==About this Structure==
==About this Structure==
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[[Category: Protein/dna]]
[[Category: Protein/dna]]
[[Category: Reaction intermediate]]
[[Category: Reaction intermediate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:23:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 22:43:58 2008''

Revision as of 19:44, 2 July 2008

Image:1lww.png

Template:STRUCTURE 1lww

Borohydride-trapped hOgg1 Intermediate Structure Co-Crystallized with 8-bromoguanine

Template:ABSTRACT PUBMED 12592398

About this Structure

1LWW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Product-assisted catalysis in base-excision DNA repair., Fromme JC, Bruner SD, Yang W, Karplus M, Verdine GL, Nat Struct Biol. 2003 Mar;10(3):204-11. PMID:12592398

Page seeded by OCA on Wed Jul 2 22:43:58 2008

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