1m32

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1m32.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1m32.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1m32| PDB=1m32 | SCENE= }}
{{STRUCTURE_1m32| PDB=1m32 | SCENE= }}
-
'''Crystal Structure of 2-aminoethylphosphonate Transaminase'''
+
===Crystal Structure of 2-aminoethylphosphonate Transaminase===
-
==Overview==
+
<!--
-
Phosphonates allow certain organisms to thrive in otherwise hostile environments, and 2-aminoethylphosphonate (AEP) is a precursor of many cellular phosphonates. AEP transaminase (AEPT) is an enzyme essential to phosphonate synthesis and degradation pathways. The crystal structure of AEP transaminase was determined by multiwavelength anomalous diffraction of 66 selenium atoms. The refined structure at 2.2 A resolution revealed an overall fold and active site location similar to those of the dimeric, two-domain structure of type I aminotransferases. The active site contains a cofactor, pyridoxal 5'-phosphate (PLP), and the product phosphonoacetaldehyde. Comparison with other type I aminotransferase structures shows that the PLP-protein interactions are conserved. Modeling of bound substrates and products reveals the structural basis for AEP recognition and the stereospecificity of proton elimination at the alpha-carbon and indicates conformational changes along the reaction pathway.
+
The line below this paragraph, {{ABSTRACT_PUBMED_12403617}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 12403617 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_12403617}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Zhang, H.]]
[[Category: Zhang, H.]]
[[Category: Plp-dependent aminotransferase fold]]
[[Category: Plp-dependent aminotransferase fold]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:34:19 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:06:39 2008''

Revision as of 20:06, 2 July 2008

Image:1m32.png

Template:STRUCTURE 1m32

Crystal Structure of 2-aminoethylphosphonate Transaminase

Template:ABSTRACT PUBMED 12403617

About this Structure

1M32 is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Degradation pathway of the phosphonate ciliatine: crystal structure of 2-aminoethylphosphonate transaminase., Chen CC, Zhang H, Kim AD, Howard A, Sheldrick GM, Mariano-Dunaway D, Herzberg O, Biochemistry. 2002 Nov 5;41(44):13162-9. PMID:12403617

Page seeded by OCA on Wed Jul 2 23:06:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1m32"
Personal tools