1m44

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{{STRUCTURE_1m44| PDB=1m44 | SCENE= }}
{{STRUCTURE_1m44| PDB=1m44 | SCENE= }}
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'''Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure'''
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===Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure===
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==Overview==
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AAC(2')-Ic catalyzes the coenzyme A (CoA)-dependent acetylation of the 2' hydroxyl or amino group of a broad spectrum of aminoglycosides. The crystal structure of the AAC(2')-Ic from Mycobacterium tuberculosis has been determined in the apo enzyme form and in ternary complexes with CoA and either tobramycin, kanamycin A or ribostamycin, representing the first structures of an aminoglycoside acetyltransferase bound to a drug. The overall fold of AAC(2')-Ic places it in the GCN5-related N-acetyltransferase (GNAT) superfamily. Although the physiological function of AAC(2')-Ic is uncertain, a structural analysis of these high-affinity aminoglycoside complexes suggests that the enzyme may acetylate a key biosynthetic intermediate of mycothiol, the major reducing agent in mycobacteria, and participate in the regulation of cellular redox potential.
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{{ABSTRACT_PUBMED_12161746}}
==About this Structure==
==About this Structure==
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[[Category: Vetting, M W.]]
[[Category: Vetting, M W.]]
[[Category: Coa binding motif]]
[[Category: Coa binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:36:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:09:59 2008''

Revision as of 20:10, 2 July 2008

Image:1m44.png

Template:STRUCTURE 1m44

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-APO Structure

Template:ABSTRACT PUBMED 12161746

About this Structure

1M44 is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis in complex with coenzyme A and aminoglycoside substrates., Vetting MW, Hegde SS, Javid-Majd F, Blanchard JS, Roderick SL, Nat Struct Biol. 2002 Sep;9(9):653-8. PMID:12161746

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