1m5q

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{{STRUCTURE_1m5q| PDB=1m5q | SCENE= }}
{{STRUCTURE_1m5q| PDB=1m5q | SCENE= }}
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'''Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum'''
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===Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum===
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==Overview==
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To better understand the roles of Sm proteins in forming the cores of many RNA-processing ribonucleoproteins, we determined the crystal structure of an atypical Sm-like archaeal protein (SmAP3) in which the conserved Sm domain is augmented by a previously uncharacterized, mixed alpha/beta C-terminal domain. The structure reveals an unexpected SmAP3 14-mer that is perforated by a cylindrical pore and is bound to 14 cadmium (Cd(2+)) ions. Individual heptamers adopt either "apical" or "equatorial" conformations that chelate Cd(2+) differently. SmAP3 forms supraheptameric oligomers (SmAP3)(n = 7,14,28) in solution, and assembly of the asymmetric 14-mer is modulated by differential divalent cation-binding in apical and equatorial subunits. Phylogenetic and sequence analyses substantiate SmAP3s as a unique subset of SmAPs. These results distinguish SmAP3s from other Sm proteins and provide a model for the structure and properties of Sm proteins &gt;100 residues in length, e.g., several human Sm proteins.
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{{ABSTRACT_PUBMED_12668760}}
==About this Structure==
==About this Structure==
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[[Category: Cadmium-binding site]]
[[Category: Cadmium-binding site]]
[[Category: Ob-like fold]]
[[Category: Ob-like fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:40:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:16:37 2008''

Revision as of 20:16, 2 July 2008

Image:1m5q.png

Template:STRUCTURE 1m5q

Crystal structure of a novel Sm-like archaeal protein from Pyrobaculum aerophilum

Template:ABSTRACT PUBMED 12668760

About this Structure

1M5Q is a Single protein structure of sequence from Pyrobaculum aerophilum. Full crystallographic information is available from OCA.

Reference

Structure and assembly of an augmented Sm-like archaeal protein 14-mer., Mura C, Phillips M, Kozhukhovsky A, Eisenberg D, Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4539-44. Epub 2003 Mar 31. PMID:12668760

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