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1m6s

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{{STRUCTURE_1m6s| PDB=1m6s | SCENE= }}
{{STRUCTURE_1m6s| PDB=1m6s | SCENE= }}
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'''Crystal Structure Of Threonine Aldolase'''
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===Crystal Structure Of Threonine Aldolase===
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==Overview==
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L-Threonine acetaldehyde-lyase (threonine aldolase, TA) is a pyridoxal-5'-phosphate-dependent (PLP) enzyme that catalyzes conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway. X-ray structures of Thermatoga maritima TA have been determined as the apo-enzyme at 1.8 A resolution and bound to substrate L-allo-threonine and product glycine at 1.9 and 2.0 A resolution, respectively. Despite low pairwise sequence identities, TA is a member of aspartate aminotransferase (AATase) fold family of PLP enzymes. The enzyme forms a 222 homotetramer with the PLP cofactor bound via a Schiff-base linkage to Lys199 within a domain interface. The structure reveals bound calcium and chloride ions that appear to contribute to catalysis and oligomerization, respectively. Although L-threonine and L-allo-threonine are substrates for T. maritima TA, enzymatic assays revealed a strong preference for L-allo-threonine. Structures of the external aldimines with substrate/product reveal a pair of histidines that may provide flexibility in substrate recognition. Variation in the threonine binding pocket may explain preferences for L-allo-threonine versus L-threonine among TA family members.
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(as it appears on PubMed at http://www.pubmed.gov), where 12269813 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12269813}}
==About this Structure==
==About this Structure==
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[[Category: Threonine]]
[[Category: Threonine]]
[[Category: Vitamin b12]]
[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:42:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:20:10 2008''

Revision as of 20:20, 2 July 2008

Image:1m6s.png

Template:STRUCTURE 1m6s

Crystal Structure Of Threonine Aldolase

Template:ABSTRACT PUBMED 12269813

About this Structure

1M6S is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

X-ray structures of threonine aldolase complexes: structural basis of substrate recognition., Kielkopf CL, Burley SK, Biochemistry. 2002 Oct 1;41(39):11711-20. PMID:12269813

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