1ma9

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{{STRUCTURE_1ma9| PDB=1ma9 | SCENE= }}
{{STRUCTURE_1ma9| PDB=1ma9 | SCENE= }}
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'''Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin'''
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===Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin===
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==Overview==
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The multifunctional vitamin D binding protein (DBP) is an actin-sequestering protein present in blood. The crystal structure of the actin-DBP complex was determined at 2.4 A resolution. DBP binds to actin subdomains 1 and 3 and occludes the cleft at the interface between these subdomains. Most remarkably, DBP demonstrates an unusually large actin-binding interface, far exceeding the binding-interface areas reported for other actin-binding proteins such as profilin, DNase I and gelsolin. The fast-growing side of actin monomers is blocked completely through a perfect structural fit with DBP, demonstrating how DBP effectively interferes with actin-filament formation. It establishes DBP as the hitherto best actin-sequestering protein and highlights its key role in suppressing and preventing extracellular actin polymerization.
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(as it appears on PubMed at http://www.pubmed.gov), where 12554937 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12554937}}
==About this Structure==
==About this Structure==
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[[Category: Complex formed in plasma]]
[[Category: Complex formed in plasma]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:49:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:32:47 2008''

Revision as of 20:32, 2 July 2008

Image:1ma9.png

Template:STRUCTURE 1ma9

Crystal structure of the complex of human vitamin D binding protein and rabbit muscle actin

Template:ABSTRACT PUBMED 12554937

About this Structure

1MA9 is a Protein complex structure of sequences from Homo sapiens and Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

Actin-DBP: the perfect structural fit?, Verboven C, Bogaerts I, Waelkens E, Rabijns A, Van Baelen H, Bouillon R, De Ranter C, Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):263-73. Epub 2003, Jan 23. PMID:12554937

Page seeded by OCA on Wed Jul 2 23:32:47 2008

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