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1mbj

From Proteopedia

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[[Image:1mbj.jpg|left|200px]]
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{{Seed}}
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[[Image:1mbj.png|left|200px]]
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{{STRUCTURE_1mbj| PDB=1mbj | SCENE= }}
{{STRUCTURE_1mbj| PDB=1mbj | SCENE= }}
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'''MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3'''
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===MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3===
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==Overview==
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The DNA-binding domain of c-Myb consists of three imperfect tandem repeats (R1, R2 and R3). The three repeats have similar overall architectures, each containing a helix-turn-helix variation motif. The three conserved tryptophans in each repeat participate in forming a hydrophobic core. Comparison of the three repeat structures indicated that cavities are found in the hydrophobic core of R2, which is thermally unstable. On complexation with DNA, the orientations of R2 and R3 are fixed by tight binding and their conformations are slightly changed. No significant changes occur in the chemical shifts of R1 consistent with its loose interaction with DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_7796266}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7796266 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7796266}}
==About this Structure==
==About this Structure==
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1MBJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBJ OCA].
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1MBJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MBJ OCA].
==Reference==
==Reference==
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[[Category: Zhang, R.]]
[[Category: Zhang, R.]]
[[Category: Protooncogene product]]
[[Category: Protooncogene product]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 00:51:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:37:46 2008''

Revision as of 20:37, 2 July 2008

Image:1mbj.png

Template:STRUCTURE 1mbj

MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3

Template:ABSTRACT PUBMED 7796266

About this Structure

1MBJ is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Comparison of the free and DNA-complexed forms of the DNA-binding domain from c-Myb., Ogata K, Morikawa S, Nakamura H, Hojo H, Yoshimura S, Zhang R, Aimoto S, Ametani Y, Hirata Z, Sarai A, et al., Nat Struct Biol. 1995 Apr;2(4):309-20. PMID:7796266

Page seeded by OCA on Wed Jul 2 23:37:46 2008

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