1mhc

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[[Image:1mhc.gif|left|200px]]
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{{STRUCTURE_1mhc| PDB=1mhc | SCENE= }}
{{STRUCTURE_1mhc| PDB=1mhc | SCENE= }}
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'''MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION'''
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===MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION===
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==Overview==
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H2-M3 is a class Ib MHC molecule of the mouse with a 10(4)-fold preference for binding N-formylated peptides. To elucidate the basis of this unusual specificity, we expressed and crystallized a soluble form of M3 with a formylated nonamer peptide, fMYFINILTL, and determined the structure by X-ray crystallography. M3, refined at 2.1 A resolution, resembles class la MHC molecules in its overall structure, but differs in the peptide-binding groove. The A pocket, which usually accommodates the free N-terminus of a bound peptide, is closed, and the peptide is shifted one residue, such that the P1 side chain is lodged in the B pocket. The formyl group is coordinated by His-9 and a bound water on the floor of the groove.
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(as it appears on PubMed at http://www.pubmed.gov), where 7664344 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664344}}
==About this Structure==
==About this Structure==
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[[Category: Wang, C R.]]
[[Category: Wang, C R.]]
[[Category: Histocompatibility antigen/peptide]]
[[Category: Histocompatibility antigen/peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:01:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 2 23:57:43 2008''

Revision as of 20:57, 2 July 2008

Image:1mhc.png

Template:STRUCTURE 1mhc

MODEL OF MHC CLASS I H2-M3 WITH NONAPEPTIDE FROM RAT ND1 REFINED AT 2.3 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 7664344

About this Structure

1MHC is a Protein complex structure of sequences from Mus musculus and Rattus rattus. Full crystallographic information is available from OCA.

Reference

Nonclassical binding of formylated peptide in crystal structure of the MHC class Ib molecule H2-M3., Wang CR, Castano AR, Peterson PA, Slaughter C, Lindahl KF, Deisenhofer J, Cell. 1995 Aug 25;82(4):655-64. PMID:7664344

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