1mlv

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[[Image:1mlv.gif|left|200px]]
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{{STRUCTURE_1mlv| PDB=1mlv | SCENE= }}
{{STRUCTURE_1mlv| PDB=1mlv | SCENE= }}
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'''Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase'''
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===Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase===
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==Overview==
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Protein lysine methylation by SET domain enzymes regulates chromatin structure, gene silencing, transcriptional activation, plant metabolism, and other processes. The 2.6 A resolution structure of Rubisco large subunit methyltransferase in a pseudo-bisubstrate complex with S-adenosylhomocysteine and a HEPES ion reveals an all-beta architecture for the SET domain embedded within a larger alpha-helical enzyme fold. Conserved regions of the SET domain bind S-adenosylmethionine and substrate lysine at two sites connected by a pore. We propose that methyl transfer is catalyzed by a conserved Tyr at a narrow pore connecting the sites. The cofactor enters by a "back door" on the opposite side of the enzyme from substrate, promoting highly specific protein recognition and allowing addition of multiple methyl groups.
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(as it appears on PubMed at http://www.pubmed.gov), where 12372303 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12372303}}
==About this Structure==
==About this Structure==
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[[Category: Post-translational modification]]
[[Category: Post-translational modification]]
[[Category: Set domain]]
[[Category: Set domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:23:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:17:34 2008''

Revision as of 21:17, 2 July 2008

Image:1mlv.png

Template:STRUCTURE 1mlv

Structure and Catalytic Mechanism of a SET Domain Protein Methyltransferase

Template:ABSTRACT PUBMED 12372303

About this Structure

1MLV is a Single protein structure of sequence from Pisum sativum. Full crystallographic information is available from OCA.

Reference

Structure and catalytic mechanism of a SET domain protein methyltransferase., Trievel RC, Beach BM, Dirk LM, Houtz RL, Hurley JH, Cell. 2002 Oct 4;111(1):91-103. PMID:12372303

Page seeded by OCA on Thu Jul 3 00:17:34 2008

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