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1mnb

From Proteopedia

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[[Image:1mnb.gif|left|200px]]
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{{Seed}}
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[[Image:1mnb.png|left|200px]]
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{{STRUCTURE_1mnb| PDB=1mnb | SCENE= }}
{{STRUCTURE_1mnb| PDB=1mnb | SCENE= }}
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'''BIV TAT PEPTIDE (RESIDUES 68-81), NMR, MINIMIZED AVERAGE STRUCTURE'''
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===BIV TAT PEPTIDE (RESIDUES 68-81), NMR, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The Tat protein of bovine immunodeficiency virus (BIV) binds to its target RNA, TAR, and activates transcription. A 14-amino acid arginine-rich peptide corresponding to the RNA-binding domain of BIV Tat binds specifically to BIV TAR, and biochemical and in vivo experiments have identified the amino acids and nucleotides required for binding. The solution structure of the RNA-peptide complex has now been determined by nuclear magnetic resonance spectroscopy. TAR forms a virtually continuous A-form helix with two unstacked bulged nucleotides. The peptide adopts a beta-turn conformation and sits in the major groove of the RNA. Specific contacts are apparent between critical amino acids in the peptide and bases and phosphates in the RNA. The structure is consistent with all biochemical data and demonstrates ways in which proteins can recognize the major groove of RNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_7502045}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7502045 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7502045}}
==About this Structure==
==About this Structure==
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1MNB is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNB OCA].
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1MNB is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MNB OCA].
==Reference==
==Reference==
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[[Category: Puglisi, J D.]]
[[Category: Puglisi, J D.]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:27:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:27:16 2008''

Revision as of 21:27, 2 July 2008

Image:1mnb.png

Template:STRUCTURE 1mnb

BIV TAT PEPTIDE (RESIDUES 68-81), NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 7502045

About this Structure

1MNB is a Single protein structure. Full experimental information is available from OCA.

Reference

Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex., Puglisi JD, Chen L, Blanchard S, Frankel AD, Science. 1995 Nov 17;270(5239):1200-3. PMID:7502045

Page seeded by OCA on Thu Jul 3 00:27:16 2008

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