1mog

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[[Image:1mog.gif|left|200px]]
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{{STRUCTURE_1mog| PDB=1mog | SCENE= }}
{{STRUCTURE_1mog| PDB=1mog | SCENE= }}
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'''Crystal structure of H. salinarum dodecin'''
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===Crystal structure of H. salinarum dodecin===
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==Overview==
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A novel, 68 amino acid long flavoprotein called dodecin has been discovered in the proteome of Halobacterium salinarum by inverse structural genomics. The 1.7 A crystal structure of this protein shows a dodecameric, hollow sphere-like arrangement of the protein subunits. Unlike other known flavoproteins, which bind only monomeric flavin cofactors, the structure of the dodecin oligomer comprises six riboflavin dimers. The dimerization of these riboflavins along the re-faces is mediated by aromatic, antiparallel pi staggering of their isoalloxazine moieties. A unique aromatic tetrade is formed by further sandwiching of the riboflavin dimers between the indole groups of two symmetry-related Trp36s. So far, the dodecins represent the smallest known flavoproteins. Based on the structure and the wide spread occurrences in pathogenic and soil eubacteria, a function in flavin storage or protection against radical or oxygenic stress is suggested for the dodecins.
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The line below this paragraph, {{ABSTRACT_PUBMED_12679016}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 12679016 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12679016}}
==About this Structure==
==About this Structure==
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[[Category: 23-symmetric dodecamer]]
[[Category: 23-symmetric dodecamer]]
[[Category: Binding site for dimerized riboflavin]]
[[Category: Binding site for dimerized riboflavin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:31:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:33:58 2008''

Revision as of 21:34, 2 July 2008

Image:1mog.png

Template:STRUCTURE 1mog

Crystal structure of H. salinarum dodecin

Template:ABSTRACT PUBMED 12679016

About this Structure

1MOG is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Crystal structure of halophilic dodecin: a novel, dodecameric flavin binding protein from Halobacterium salinarum., Bieger B, Essen LO, Oesterhelt D, Structure. 2003 Apr;11(4):375-85. PMID:12679016

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