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1moj

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[[Image:1moj.gif|left|200px]]
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{{STRUCTURE_1moj| PDB=1moj | SCENE= }}
{{STRUCTURE_1moj| PDB=1moj | SCENE= }}
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'''Crystal structure of an archaeal dps-homologue from Halobacterium salinarum'''
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===Crystal structure of an archaeal dps-homologue from Halobacterium salinarum===
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==Overview==
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The crystal structure of the Dps-like (Dps, DNA-protecting protein during starvation) ferritin protein DpsA from the halophile Halobacterium salinarum was determined with low endogenous iron content at 1.6-A resolution. The mechanism of iron uptake and storage was analyzed in this noncanonical ferritin by three high-resolution structures at successively increasing iron contents. In the high-iron state of the DpsA protein, up to 110 iron atoms were localized in the dodecameric protein complex. For ultimate iron storage, the archaeal ferritin shell comprises iron-binding sites for iron translocation, oxidation, and nucleation. Initial iron-protein interactions occur through acidic residues exposed along the outer surface in proximity to the iron entry pore. This narrow pore permits translocation of ions toward the ferroxidase centers via two discrete steps. Iron oxidation proceeds by transient formation of tri-iron ferroxidase centers. Iron storage by biomineralization inside the ferritin shell occurs at two iron nucleation centers. Here, a single iron atom provides a structural seed for iron-oxide cluster formation. The clusters with up to five iron atoms adopt a geometry that is different from natural biominerals like magnetite but resembles iron clusters so far known only from bioinorganic model compounds.
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(as it appears on PubMed at http://www.pubmed.gov), where 15365182 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15365182}}
==About this Structure==
==About this Structure==
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[[Category: Four-helix bundle]]
[[Category: Four-helix bundle]]
[[Category: Halophilic]]
[[Category: Halophilic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:31:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:33:58 2008''

Revision as of 21:34, 2 July 2008

Image:1moj.png

Template:STRUCTURE 1moj

Crystal structure of an archaeal dps-homologue from Halobacterium salinarum

Template:ABSTRACT PUBMED 15365182

About this Structure

1MOJ is a Single protein structure of sequence from Halobacterium salinarum. Full crystallographic information is available from OCA.

Reference

Iron-oxo clusters biomineralizing on protein surfaces: structural analysis of Halobacterium salinarum DpsA in its low- and high-iron states., Zeth K, Offermann S, Essen LO, Oesterhelt D, Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13780-5. Epub 2004 Sep 13. PMID:15365182

Page seeded by OCA on Thu Jul 3 00:33:58 2008

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