1mpg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1mpg.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1mpg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1mpg| PDB=1mpg | SCENE= }}
{{STRUCTURE_1mpg| PDB=1mpg | SCENE= }}
-
'''3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI'''
+
===3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI===
-
==Overview==
+
<!--
-
Base-excision DNA repair proteins that target alkylation damage act on a variety of seemingly dissimilar adducts, yet fail to recognize other closely related lesions. The 1.8 A crystal structure of the monofunctional DNA glycosylase AlkA (E. coli 3-methyladenine-DNA glycosylase II) reveals a large hydrophobic cleft unusually rich in aromatic residues. An Asp residue projecting into this cleft is essential for catalysis, and it governs binding specificity for mechanism-based inhibitors. We propose that AlkA recognizes electron-deficient methylated bases through pi-donor/acceptor interactions involving the electron-rich aromatic cleft. Remarkably, AlkA is similar in fold and active site location to the bifunctional glycosylase/lyase endonuclease III, suggesting the two may employ fundamentally related mechanisms for base excision.
+
The line below this paragraph, {{ABSTRACT_PUBMED_8706136}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 8706136 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_8706136}}
==About this Structure==
==About this Structure==
Line 35: Line 39:
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Methylation]]
[[Category: Methylation]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:33:38 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:41:50 2008''

Revision as of 21:41, 2 July 2008

Image:1mpg.png

Template:STRUCTURE 1mpg

3-METHYLADENINE DNA GLYCOSYLASE II FROM ESCHERICHIA COLI

Template:ABSTRACT PUBMED 8706136

About this Structure

1MPG is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for the excision repair of alkylation-damaged DNA., Labahn J, Scharer OD, Long A, Ezaz-Nikpay K, Verdine GL, Ellenberger TE, Cell. 1996 Jul 26;86(2):321-9. PMID:8706136

Page seeded by OCA on Thu Jul 3 00:41:50 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mpg"
Personal tools