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1mpu

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{{STRUCTURE_1mpu| PDB=1mpu | SCENE= }}
{{STRUCTURE_1mpu| PDB=1mpu | SCENE= }}
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'''Crystal Structure of the free human NKG2D immunoreceptor'''
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===Crystal Structure of the free human NKG2D immunoreceptor===
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==Overview==
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Engagement of diverse protein ligands (MIC-A/B, ULBP, Rae-1, or H60) by NKG2D immunoreceptors mediates elimination of tumorigenic or virally infected cells by natural killer and T cells. Three previous NKG2D-ligand complex structures show the homodimeric receptor interacting with the monomeric ligands in similar 2:1 complexes, with an equivalent surface on each NKG2D monomer binding intimately to a total of six distinct ligand surfaces. Here, the crystal structure of free human NKG2D and in silico and in vitro alanine-scanning mutagenesis analyses of the complex interfaces indicate that NKG2D recognition degeneracy is not explained by a classical induced-fit mechanism. Rather, the divergent ligands appear to utilize different strategies to interact with structurally conserved elements of the consensus NKG2D binding site.
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(as it appears on PubMed at http://www.pubmed.gov), where 12679019 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12679019}}
==About this Structure==
==About this Structure==
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[[Category: Strong, R K.]]
[[Category: Strong, R K.]]
[[Category: C-type lectin-like domain]]
[[Category: C-type lectin-like domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:34:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:45:15 2008''

Revision as of 21:45, 2 July 2008

Image:1mpu.png

Template:STRUCTURE 1mpu

Crystal Structure of the free human NKG2D immunoreceptor

Template:ABSTRACT PUBMED 12679019

About this Structure

1MPU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:12679019

Page seeded by OCA on Thu Jul 3 00:45:15 2008

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