1mqb

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[[Image:1mqb.gif|left|200px]]
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{{STRUCTURE_1mqb| PDB=1mqb | SCENE= }}
{{STRUCTURE_1mqb| PDB=1mqb | SCENE= }}
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'''Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase'''
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===Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase===
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==Overview==
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Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors.
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(as it appears on PubMed at http://www.pubmed.gov), where 12467573 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12467573}}
==About this Structure==
==About this Structure==
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[[Category: Thompson, D A.]]
[[Category: Thompson, D A.]]
[[Category: Tyrosine protein kinase]]
[[Category: Tyrosine protein kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:35:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 00:52:51 2008''

Revision as of 21:52, 2 July 2008

Image:1mqb.png

Template:STRUCTURE 1mqb

Crystal Structure of Ephrin A2 (ephA2) Receptor Protein Kinase

Template:ABSTRACT PUBMED 12467573

About this Structure

1MQB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of the cancer-related Aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography., Nowakowski J, Cronin CN, McRee DE, Knuth MW, Nelson CG, Pavletich NP, Rogers J, Sang BC, Scheibe DN, Swanson RV, Thompson DA, Structure. 2002 Dec;10(12):1659-67. PMID:12467573

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