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3php

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{{STRUCTURE_3php| PDB=3php | SCENE= }}
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'''STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING'''
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===STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING===
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==Overview==
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The solution structure of an RNA-hairpin present in the pseudoknot, which is found at the 3'-terminus of turnip yellow mosaic virus genomic RNA, has been solved by nuclear magnetic resonance spectroscopy. The loop, which contains the sequence 5'-GGGUCA-3', was found to be highly structured and, contrary to expectations, does not attain its stability through GA or GC base pair formation but by triple interactions between the tilted adenosine and the minor groove sides of the first two guanosines. Interestingly, a very similar conformation was found for the cognate pseudoknot, implying that the 3'-hairpin is preformed for folding into a pseudoknotted structure. These findings suggest a mechanism of 'predetermined-fit' as a principle in RNA folding.
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(as it appears on PubMed at http://www.pubmed.gov), where 9857204 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9857204}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PHP OCA].
==Reference==
==Reference==
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[[Category: Rna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:10:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:02:10 2008''

Revision as of 10:02, 3 July 2008

Image:3php.png

Template:STRUCTURE 3php

STRUCTURE OF THE 3' HAIRPIN OF THE TYMV PSEUDOKNOT: PREFORMATION IN RNA FOLDING

Template:ABSTRACT PUBMED 9857204

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the 3'-hairpin of the TYMV pseudoknot: preformation in RNA folding., Kolk MH, van der Graaf M, Fransen CT, Wijmenga SS, Pleij CW, Heus HA, Hilbers CW, EMBO J. 1998 Dec 15;17(24):7498-504. PMID:9857204

Page seeded by OCA on Thu Jul 3 13:02:10 2008

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