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3ygs

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{{STRUCTURE_3ygs| PDB=3ygs | SCENE= }}
{{STRUCTURE_3ygs| PDB=3ygs | SCENE= }}
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'''APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9'''
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===APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9===
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==Overview==
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Caspase-9-mediated apoptosis (programmed cell death) plays a central role in the development and homeostasis of all multicellular organisms. Mature caspase-9 is derived from its procaspase precursor as a result of recruitment by the activating factor Apaf-1. The crystal structures of the caspase-recruitment domain of Apaf-1 by itself and in complex with the prodomain of procaspase-9 have been determined at 1.6 and 2.5 A resolution, respectively. These structures and other evidence reveal that each molecule of Apaf-1 interacts with a molecule of procaspase-9 through two highly charged and complementary surfaces formed by non-conserved residues; these surfaces determine recognition specificity through networks of intermolecular hydrogen bonds and van der Waals interactions. Mutation of the important interface residues in procaspase-9 or Apaf-1 prevents or reduces activation of procaspase-9 in a cell-free system. Wild-type, but not mutant, prodomains of caspase-9 completely inhibit catalytic processing of procaspase-9. Furthermore, analysis of homologues from Caenorhabditis elegans indicates that recruitment of CED-3 by CED-4 is probably mediated by the same set of conserved structural motifs, with a corresponding change in the specificity-determining residues.
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{{ABSTRACT_PUBMED_10376594}}
==About this Structure==
==About this Structure==
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[[Category: Caspase recruitment]]
[[Category: Caspase recruitment]]
[[Category: Recognition complex]]
[[Category: Recognition complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:15:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 13:13:30 2008''

Revision as of 10:13, 3 July 2008

Image:3ygs.png

Template:STRUCTURE 3ygs

APAF-1 CARD IN COMPLEX WITH PRODOMAIN OF PROCASPASE-9

Template:ABSTRACT PUBMED 10376594

About this Structure

3YGS is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1., Qin H, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi Y, Nature. 1999 Jun 10;399(6736):549-57. PMID:10376594

Page seeded by OCA on Thu Jul 3 13:13:30 2008

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