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7req

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[[Image:7req.gif|left|200px]]
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{{Seed}}
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[[Image:7req.png|left|200px]]
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{{STRUCTURE_7req| PDB=7req | SCENE= }}
{{STRUCTURE_7req| PDB=7req | SCENE= }}
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'''METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX'''
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===METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX===
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==Overview==
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X-ray crystal structures of methylmalonyl-CoA mutase in complexes with substrate methylmalonyl-CoA and inhibitors 2-carboxypropyl-CoA and 3-carboxypropyl-CoA (substrate and product analogues) show that the enzyme-substrate interactions change little during the course of the rearrangement reaction, in contrast to the large conformational change on substrate binding. The substrate complex shows a 5'-deoxyadenine molecule in the active site, bound weakly and not attached to the cobalt atom of coenzyme B12, rotated and shifted from its position in the substrate-free adenosylcobalamin complex. The position of Tyralpha89 close to the substrate explains the stereochemical selectivity of the enzyme for (2R)-methylmalonyl-CoA.
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(as it appears on PubMed at http://www.pubmed.gov), where 10387043 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10387043}}
==About this Structure==
==About this Structure==
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[[Category: Isomerase]]
[[Category: Isomerase]]
[[Category: Mutase]]
[[Category: Mutase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 22:47:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 3 14:56:09 2008''

Revision as of 11:56, 3 July 2008

Image:7req.png

Template:STRUCTURE 7req

METHYLMALONYL-COA MUTASE, 2-CARBOXYPROPYL-COA INHIBITOR COMPLEX

Template:ABSTRACT PUBMED 10387043

About this Structure

7REQ is a Protein complex structure of sequences from Propionibacterium freudenreichii subsp. shermanii. Full crystallographic information is available from OCA.

Reference

Crystal structure of substrate complexes of methylmalonyl-CoA mutase., Mancia F, Smith GA, Evans PR, Biochemistry. 1999 Jun 22;38(25):7999-8005. PMID:10387043

Page seeded by OCA on Thu Jul 3 14:56:09 2008

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