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2f95

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{{STRUCTURE_2f95| PDB=2f95 | SCENE= }}
{{STRUCTURE_2f95| PDB=2f95 | SCENE= }}
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'''M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure'''
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===M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure===
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==Overview==
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The microbial phototaxis receptor sensory rhodopsin II (NpSRII, also named phoborhodopsin) mediates the photophobic response of the haloarchaeon Natronomonas pharaonis by modulating the swimming behaviour of the bacterium. After excitation by blue-green light NpSRII triggers, by means of a tightly bound transducer protein (NpHtrII), a signal transduction chain homologous with the two-component system of eubacterial chemotaxis. Two molecules of NpSRII and two molecules of NpHtrII form a 2:2 complex in membranes as shown by electron paramagnetic resonance and X-ray structure analysis. Here we present X-ray structures of the photocycle intermediates K and late M (M2) explaining the evolution of the signal in the receptor after retinal isomerization and the transfer of the signal to the transducer in the complex. The formation of late M has been correlated with the formation of the signalling state. The observed structural rearrangements allow us to propose the following mechanism for the light-induced activation of the signalling complex. On excitation by light, retinal isomerization leads in the K state to a rearrangement of a water cluster that partly disconnects two helices of the receptor. In the transition to late M the changes in the hydrogen bond network proceed further. Thus, in late M state an altered tertiary structure establishes the signalling state of the receptor. The transducer responds to the activation of the receptor by a clockwise rotation of about 15 degrees of helix TM2 and a displacement of this helix by 0.9 A at the cytoplasmic surface.
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(as it appears on PubMed at http://www.pubmed.gov), where 16452929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16452929}}
==About this Structure==
==About this Structure==
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[[Category: Photocycle state]]
[[Category: Photocycle state]]
[[Category: Signal transduction]]
[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:36:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:35:52 2008''

Revision as of 09:35, 10 July 2008

Image:2f95.png

Template:STRUCTURE 2f95

M intermediate structure of sensory rhodopsin II/transducer complex in combination with the ground state structure

Template:ABSTRACT PUBMED 16452929

About this Structure

2F95 is a Protein complex structure of sequences from Natronomonas pharaonis. Full crystallographic information is available from OCA.

Reference

Development of the signal in sensory rhodopsin and its transfer to the cognate transducer., Moukhametzianov R, Klare JP, Efremov R, Baeken C, Goppner A, Labahn J, Engelhard M, Buldt G, Gordeliy VI, Nature. 2006 Mar 2;440(7080):115-9. Epub 2006 Feb 1. PMID:16452929

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