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1vyb

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[[Image:1vyb.jpg|left|200px]]
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{{STRUCTURE_1vyb| PDB=1vyb | SCENE= }}
{{STRUCTURE_1vyb| PDB=1vyb | SCENE= }}
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'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''
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===ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P===
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==Overview==
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The human L1 endonuclease (L1-EN) is encoded by the non-LTR retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million retrotransposition events in the history of the human genome, contributing more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is related to the well-understood human DNA repair endonuclease APE1, and its nicking specificity is a major determinant for retrotransposon integration site selection. The crystal structure of human L1 endonuclease is the first of a retrotransposon-encoded protein and a prototype for retrotransposon-encoded endonucleases involved in target-primed reverse transcription. Structure-based endonuclease alignments reveal a conserved threonine in addition to previously identified invariant residues and suggest that DNA recognition proceeds via the accommodation of an extrahelical nucleotide within a pocket of the enzyme. The present analysis will help to refine phylogenetic and functional relationships among metal-dependent phosphohydrolases and provides a basis for manipulating non-LTR retrotransposon integration site selection.
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The line below this paragraph, {{ABSTRACT_PUBMED_15274918}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15274918 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15274918}}
==About this Structure==
==About this Structure==
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[[Category: Rna-directed dna polymerase]]
[[Category: Rna-directed dna polymerase]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:54:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:53:11 2008''

Revision as of 09:53, 10 July 2008

Image:1vyb.png

Template:STRUCTURE 1vyb

ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P

Template:ABSTRACT PUBMED 15274918

About this Structure

1VYB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon., Weichenrieder O, Repanas K, Perrakis A, Structure. 2004 Jun;12(6):975-86. PMID:15274918

Page seeded by OCA on Thu Jul 10 12:53:11 2008

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