1vyb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1vyb.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1vyb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1vyb| PDB=1vyb | SCENE= }}
{{STRUCTURE_1vyb| PDB=1vyb | SCENE= }}
-
'''ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P'''
+
===ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P===
-
==Overview==
+
<!--
-
The human L1 endonuclease (L1-EN) is encoded by the non-LTR retrotransposon LINE-1 (L1). L1 is responsible for more than 1.5 million retrotransposition events in the history of the human genome, contributing more than a quarter to human genomic DNA (L1 and Alu elements). L1-EN is related to the well-understood human DNA repair endonuclease APE1, and its nicking specificity is a major determinant for retrotransposon integration site selection. The crystal structure of human L1 endonuclease is the first of a retrotransposon-encoded protein and a prototype for retrotransposon-encoded endonucleases involved in target-primed reverse transcription. Structure-based endonuclease alignments reveal a conserved threonine in addition to previously identified invariant residues and suggest that DNA recognition proceeds via the accommodation of an extrahelical nucleotide within a pocket of the enzyme. The present analysis will help to refine phylogenetic and functional relationships among metal-dependent phosphohydrolases and provides a basis for manipulating non-LTR retrotransposon integration site selection.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15274918}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15274918 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15274918}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Rna-directed dna polymerase]]
[[Category: Rna-directed dna polymerase]]
[[Category: Transferase]]
[[Category: Transferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:54:34 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jul 10 12:53:11 2008''

Revision as of 09:53, 10 July 2008

Image:1vyb.png

Template:STRUCTURE 1vyb

ENDONUCLEASE DOMAIN OF HUMAN LINE1 ORF2P

Template:ABSTRACT PUBMED 15274918

About this Structure

1VYB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the targeting endonuclease of the human LINE-1 retrotransposon., Weichenrieder O, Repanas K, Perrakis A, Structure. 2004 Jun;12(6):975-86. PMID:15274918

Page seeded by OCA on Thu Jul 10 12:53:11 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1vyb"
Personal tools