1p58

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[[Image:1p58.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1p58| PDB=1p58 | SCENE= }}
{{STRUCTURE_1p58| PDB=1p58 | SCENE= }}
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'''Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction'''
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===Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction===
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==Overview==
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Improved technology for reconstructing cryo-electron microscopy (cryo-EM) images has now made it possible to determine secondary structural features of membrane proteins in enveloped viruses. The structure of mature dengue virus particles was determined to a resolution of 9.5 A by cryo-EM and image reconstruction techniques, establishing the secondary structural disposition of the 180 envelope (E) and 180 membrane (M) proteins in the lipid envelope. The alpha-helical 'stem' regions of the E molecules, as well as part of the N-terminal section of the M proteins, are buried in the outer leaflet of the viral membrane. The 'anchor' regions of E and the M proteins each form antiparallel E-E and M-M transmembrane alpha-helices, leaving their C termini on the exterior of the viral membrane, consistent with the predicted topology of the unprocessed polyprotein. This is one of only a few determinations of the disposition of transmembrane proteins in situ and shows that the nucleocapsid core and envelope proteins do not have a direct interaction in the mature virus.
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The line below this paragraph, {{ABSTRACT_PUBMED_14528291}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 14528291 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14528291}}
==About this Structure==
==About this Structure==
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[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
[[Category: Membrane protein m]]
[[Category: Membrane protein m]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:42:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 07:58:56 2008''

Revision as of 04:58, 23 July 2008

Image:1p58.png

Template:STRUCTURE 1p58

Complex Organization of Dengue Virus Membrane Proteins as Revealed by 9.5 Angstrom Cryo-EM reconstruction

Template:ABSTRACT PUBMED 14528291

About this Structure

1P58 is a Protein complex structure of sequences from Dengue virus 2. Full crystallographic information is available from OCA.

Reference

Visualization of membrane protein domains by cryo-electron microscopy of dengue virus., Zhang W, Chipman PR, Corver J, Johnson PR, Zhang Y, Mukhopadhyay S, Baker TS, Strauss JH, Rossmann MG, Kuhn RJ, Nat Struct Biol. 2003 Nov;10(11):907-12. Epub 2003 Oct 5. PMID:14528291

Page seeded by OCA on Wed Jul 23 07:58:56 2008

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