2dup

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{{STRUCTURE_2dup| PDB=2dup | SCENE= }}
{{STRUCTURE_2dup| PDB=2dup | SCENE= }}
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'''Crystal structure of VIP36 exoplasmic/lumenal domain, metal-free form'''
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===Crystal structure of VIP36 exoplasmic/lumenal domain, metal-free form===
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==Overview==
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VIP36 functions as a transport lectin for trafficking certain high mannose type glycoproteins in the secretory pathway. Here we report the crystal structure of VIP36 exoplasmic/luminal domain comprising a carbohydrate recognition domain and a stalk domain. The structures of VIP36 in complex with Ca(2+) and mannosyl ligands are also described. The carbohydrate recognition domain is composed of a 17-stranded antiparallel beta-sandwich and binds one Ca(2+) adjoining the carbohydrate-binding site. The structure reveals that a coordinated Ca(2+) ion orients the side chains of Asp(131), Asn(166), and His(190) for carbohydrate binding. This result explains the Ca(2+)-dependent carbohydrate binding of this protein. The Man-alpha-1,2-Man-alpha-1,2-Man, which corresponds to the D1 arm of high mannose type glycan, is recognized by eight residues through extensive hydrogen bonds. The complex structures reveal the structural basis for high mannose type glycoprotein recognition by VIP36 in a Ca(2+)-dependent and D1 arm-specific manner.
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(as it appears on PubMed at http://www.pubmed.gov), where 17652092 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17652092}}
==About this Structure==
==About this Structure==
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[[Category: Cargo receptor]]
[[Category: Cargo receptor]]
[[Category: Protein transport]]
[[Category: Protein transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 01:24:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:17:33 2008''

Revision as of 09:17, 27 July 2008

Image:2dup.png

Template:STRUCTURE 2dup

Crystal structure of VIP36 exoplasmic/lumenal domain, metal-free form

Template:ABSTRACT PUBMED 17652092

About this Structure

2DUP is a Single protein structure of sequence from Canis lupus familiaris. Full crystallographic information is available from OCA.

Reference

Structural basis for recognition of high mannose type glycoproteins by mammalian transport lectin VIP36., Satoh T, Cowieson NP, Hakamata W, Ideo H, Fukushima K, Kurihara M, Kato R, Yamashita K, Wakatsuki S, J Biol Chem. 2007 Sep 21;282(38):28246-55. Epub 2007 Jul 25. PMID:17652092

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