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1yq6

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[[Image:1yq6.gif|left|200px]]
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{{STRUCTURE_1yq6| PDB=1yq6 | SCENE= }}
{{STRUCTURE_1yq6| PDB=1yq6 | SCENE= }}
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'''PRD1 vertex protein P5'''
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===PRD1 vertex protein P5===
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==Overview==
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Comparisons of bacteriophage PRD1 and adenovirus protein structures and virion architectures have been instrumental in unraveling an evolutionary relationship and have led to a proposal of a phylogeny-based virus classification. The structure of the PRD1 spike protein P5 provides further insight into the evolution of viral proteins. The crystallized P5 fragment comprises two structural domains: a globular knob and a fibrous shaft. The head folds into a ten-stranded jelly roll beta barrel, which is structurally related to the tumor necrosis factor (TNF) and the PRD1 coat protein domains. The shaft domain is a structural counterpart to the adenovirus spike shaft. The structural relationships between PRD1, TNF, and adenovirus proteins suggest that the vertex proteins may have originated from an ancestral TNF-like jelly roll coat protein via a combination of gene duplication and deletion.
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(as it appears on PubMed at http://www.pubmed.gov), where 15837420 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15837420}}
==About this Structure==
==About this Structure==
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[[Category: Beta-jelly-roll]]
[[Category: Beta-jelly-roll]]
[[Category: Beta-spiral]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:19:20 2008''

Revision as of 09:19, 27 July 2008

Image:1yq6.png

Template:STRUCTURE 1yq6

PRD1 vertex protein P5

Template:ABSTRACT PUBMED 15837420

About this Structure

1YQ6 is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.

Reference

The structure of the bacteriophage PRD1 spike sheds light on the evolution of viral capsid architecture., Merckel MC, Huiskonen JT, Bamford DH, Goldman A, Tuma R, Mol Cell. 2005 Apr 15;18(2):161-70. PMID:15837420

Page seeded by OCA on Sun Jul 27 12:19:20 2008

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