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1v6r

From Proteopedia

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{{STRUCTURE_1v6r| PDB=1v6r | SCENE= }}
{{STRUCTURE_1v6r| PDB=1v6r | SCENE= }}
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'''Solution Structure of Endothelin-1 with its C-terminal Folding'''
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===Solution Structure of Endothelin-1 with its C-terminal Folding===
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==Overview==
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Distributed computing has been implemented to the solution structure determination of endothelin-1 to evaluate efficiency of the method for NMR constraint-based structure calculations. A key target of the investigation was determination of the C-terminal folding of the peptide, which had been dispersed in previous studies of NMR, despite its pharmacological significances. With use of tens of thousands of random initial structures to explore the conformational space comprehensively, we determined high-resolution structures with good convergences of C-terminal as well as previously defined N-terminal structures. The previous studies had missed the C-terminal convergence because of initial structure dependencies trapped in localized folding of the N-terminal region, which are strongly constricted by two disulfide bonds.
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The line below this paragraph, {{ABSTRACT_PUBMED_15070353}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15070353 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15070353}}
==About this Structure==
==About this Structure==
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1V6R is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA].
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1V6R is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1V6R OCA].
==Reference==
==Reference==
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[[Category: Endothelin]]
[[Category: Endothelin]]
[[Category: G-protein coupled-receptor ligand]]
[[Category: G-protein coupled-receptor ligand]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 12:09:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:33:17 2008''

Revision as of 09:33, 27 July 2008

Image:1v6r.png

Template:STRUCTURE 1v6r

Solution Structure of Endothelin-1 with its C-terminal Folding

Template:ABSTRACT PUBMED 15070353

About this Structure

1V6R is a Single protein structure. Full experimental information is available from OCA.

Reference

Distributed computing and NMR constraint-based high-resolution structure determination: applied for bioactive Peptide endothelin-1 to determine C-terminal folding., Takashima H, Mimura N, Ohkubo T, Yoshida T, Tamaoki H, Kobayashi Y, J Am Chem Soc. 2004 Apr 14;126(14):4504-5. PMID:15070353

Page seeded by OCA on Sun Jul 27 12:33:17 2008

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