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1tuk

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[[Image:1tuk.gif|left|200px]]
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{{STRUCTURE_1tuk| PDB=1tuk | SCENE= }}
{{STRUCTURE_1tuk| PDB=1tuk | SCENE= }}
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'''Crystal stucture of liganted type 2 non specific lipid transfer protein from wheat'''
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===Crystal stucture of liganted type 2 non specific lipid transfer protein from wheat===
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==Overview==
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In plants, a family of ubiquitous proteins named non-specific lipid-transfer proteins (ns-LTPs) facilitates the transfer of fatty acids, phospholipids and steroids between membranes. Recent data suggest that these secreted proteins play a key role in the formation of cuticular wax layers and in defence mechanisms against pathogens. In this study, X-ray crystallography has been used to examine the structural details of the interaction between a wheat type 2 ns-LTP and a lipid, L-alpha-palmitoyl-phosphatidyl glycerol. This crystal structure was solved ab initio at 1.12 A resolution by direct methods. The typical alpha-helical bundle fold of this protein is maintained by four disulfide bridges and delineates two hydrophobic cavities. The inner surface of the main cavity is lined by non-polar residues that provide a hydrophobic environment for the palmitoyl moiety of the lipid. The head-group region of this lipid protrudes from the surface and makes several polar interactions with a conserved patch of basic residues at the entrance of the pocket. The alkyl chain of a second lipid is bound within an adjacent smaller cavity. The structure shows that binding of the lipid tails to the protein involves extensive hydrophobic interactions.
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The line below this paragraph, {{ABSTRACT_PUBMED_15805594}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15805594 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15805594}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of a liganded type 2 non-specific lipid-transfer protein from wheat and the molecular basis of lipid binding., Hoh F, Pons JL, Gautier MF, de Lamotte F, Dumas C, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):397-406. Epub 2005, Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15805594 15805594]
Structure of a liganded type 2 non-specific lipid-transfer protein from wheat and the molecular basis of lipid binding., Hoh F, Pons JL, Gautier MF, de Lamotte F, Dumas C, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):397-406. Epub 2005, Mar 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15805594 15805594]
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Refined solution structure of a liganded type 2 wheat nonspecific lipid transfer protein., Pons JL, de Lamotte F, Gautier MF, Delsuc MA, J Biol Chem. 2003 Apr 18;278(16):14249-56. Epub 2003 Jan 13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12525478 12525478]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Triticum aestivum]]
[[Category: Triticum aestivum]]
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[[Category: Lipid transfer protein]]
[[Category: Lipid transfer protein]]
[[Category: Ns-ltp2]]
[[Category: Ns-ltp2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:23:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:43:00 2008''

Revision as of 09:43, 27 July 2008

Image:1tuk.png

Template:STRUCTURE 1tuk

Crystal stucture of liganted type 2 non specific lipid transfer protein from wheat

Template:ABSTRACT PUBMED 15805594

About this Structure

1TUK is a Single protein structure of sequence from Triticum aestivum. Full crystallographic information is available from OCA.

Reference

Structure of a liganded type 2 non-specific lipid-transfer protein from wheat and the molecular basis of lipid binding., Hoh F, Pons JL, Gautier MF, de Lamotte F, Dumas C, Acta Crystallogr D Biol Crystallogr. 2005 Apr;61(Pt 4):397-406. Epub 2005, Mar 24. PMID:15805594

Refined solution structure of a liganded type 2 wheat nonspecific lipid transfer protein., Pons JL, de Lamotte F, Gautier MF, Delsuc MA, J Biol Chem. 2003 Apr 18;278(16):14249-56. Epub 2003 Jan 13. PMID:12525478

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