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1xbt

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{{STRUCTURE_1xbt| PDB=1xbt | SCENE= }}
{{STRUCTURE_1xbt| PDB=1xbt | SCENE= }}
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'''Crystal Structure of Human Thymidine Kinase 1'''
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===Crystal Structure of Human Thymidine Kinase 1===
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==Overview==
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Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs such as 3'-azido-3'-deoxythymidine (AZT). We have now determined the structures of the TK1 family, the human and Ureaplasma urealyticum enzymes, in complex with the feedback inhibitor dTTP. The TK1s have a tetrameric structure in which each subunit contains an alpha/beta-domain that is similar to ATPase domains of members of the RecA structural family and a domain containing a structural zinc. The zinc ion connects beta-structures at the root of a beta-ribbon that forms a stem that widens to a lasso-type loop. The thymidine of dTTP is hydrogen-bonded to main-chain atoms predominantly coming from the lasso loop. This binding is in contrast to other deoxyribonucleoside kinases where specific interactions occur with side chains. The TK1 structure differs fundamentally from the structures of the other deoxyribonucleoside kinases, indicating a different evolutionary origin.
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(as it appears on PubMed at http://www.pubmed.gov), where 15611477 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15611477}}
==About this Structure==
==About this Structure==
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[[Category: Feedback inhibitor]]
[[Category: Feedback inhibitor]]
[[Category: Zinc-binding domain]]
[[Category: Zinc-binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 14:49:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:50:59 2008''

Revision as of 09:50, 27 July 2008

Image:1xbt.png

Template:STRUCTURE 1xbt

Crystal Structure of Human Thymidine Kinase 1

Template:ABSTRACT PUBMED 15611477

About this Structure

1XBT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of thymidine kinase 1 of human and mycoplasmic origin., Welin M, Kosinska U, Mikkelsen NE, Carnrot C, Zhu C, Wang L, Eriksson S, Munch-Petersen B, Eklund H, Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):17970-5. Epub 2004 Dec 20. PMID:15611477

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