1nb4

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{{STRUCTURE_1nb4| PDB=1nb4 | SCENE= }}
{{STRUCTURE_1nb4| PDB=1nb4 | SCENE= }}
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'''HC-J4 RNA polymerase apo-form'''
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===HC-J4 RNA polymerase apo-form===
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==Overview==
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Several crystal structures of the hepatitis C virus NS5B protein (genotype-1b, strain J4) complexed with metal ions, single-stranded RNA or nucleoside-triphosphates have been determined. These complexes illustrate how conserved amino acid side-chains, together with essential structural features within the active site, control nucleotide binding and likely mediate de-novo initiation. The incoming nucleotide interacts with several basic residues from an extension on the NS5B fingers domain, a beta-hairpin from the NS5B thumb domain and the C-terminal arm. The modular, bi-partite fingers domain carries a long binding groove which guides the template towards the catalytic site. The apo-polymerase structure provides unprecedented insights into potential non-nucleoside inhibitor binding sites located between palm and thumb near motif E, which is unique to RNA polymerases and reverse transcriptases.
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{{ABSTRACT_PUBMED_12589751}}
==About this Structure==
==About this Structure==
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[[Category: Replication]]
[[Category: Replication]]
[[Category: Rna polymerase]]
[[Category: Rna polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:15:37 2008''

Revision as of 10:15, 27 July 2008

Image:1nb4.png

Template:STRUCTURE 1nb4

HC-J4 RNA polymerase apo-form

Template:ABSTRACT PUBMED 12589751

About this Structure

1NB4 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Substrate complexes of hepatitis C virus RNA polymerase (HC-J4): structural evidence for nucleotide import and de-novo initiation., O'Farrell D, Trowbridge R, Rowlands D, Jager J, J Mol Biol. 2003 Feb 28;326(4):1025-35. PMID:12589751

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