2jgo

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[[Image:2jgo.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2jgo| PDB=2jgo | SCENE= }}
{{STRUCTURE_2jgo| PDB=2jgo | SCENE= }}
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'''STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C'''
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===STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C===
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==Overview==
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Arsenic, a contaminant of water supplies worldwide, is one of the most toxic inorganic ions. Despite arsenic's health impact, there is relatively little structural detail known about its interactions with proteins. Bacteria such as Escherichia coli have evolved arsenic resistance using the Ars operon that is regulated by ArsR, a repressor protein that dissociates from DNA when As(III) binds. This protein undergoes a critical conformational change upon binding As(III) with three cysteine residues. Unfortunately, structures of ArsR with or without As(III) have not been reported. Alternatively, de novo designed peptides can bind As(III) in an endo configuration within a thiolate-rich environment consistent with that proposed for both ArsR and ArsD. We report the structure of the As(III) complex of Coil Ser L9C to a 1.8-A resolution, providing x-ray characterization of As(III) in a Tris thiolate protein environment and allowing a structural basis by which to understand arsenated ArsR.
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(as it appears on PubMed at http://www.pubmed.gov), where 17609383 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17609383}}
==About this Structure==
==About this Structure==
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[[Category: De novo protein]]
[[Category: De novo protein]]
[[Category: Three-stranded coiled coil]]
[[Category: Three-stranded coiled coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:53:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:31:10 2008''

Revision as of 10:31, 27 July 2008

Image:2jgo.png

Template:STRUCTURE 2jgo

STUCTURE OF THE ARSENATED DE NOVO DESIGNED PEPTIDE COIL SER L9C

Template:ABSTRACT PUBMED 17609383

About this Structure

2JGO is a Single protein structure. Full crystallographic information is available from OCA.

Reference

Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils., Touw DS, Nordman CE, Stuckey JA, Pecoraro VL, Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11969-74. Epub 2007 Jul 3. PMID:17609383

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