1uw4

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{{STRUCTURE_1uw4| PDB=1uw4 | SCENE= }}
{{STRUCTURE_1uw4| PDB=1uw4 | SCENE= }}
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'''THE STRUCTURAL BASIS OF THE INTERACTION BETWEEN NONSENSE MEDIATED DECAY FACTORS UPF2 AND UPF3'''
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===THE STRUCTURAL BASIS OF THE INTERACTION BETWEEN NONSENSE MEDIATED DECAY FACTORS UPF2 AND UPF3===
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==Overview==
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Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism by which eukaryotic cells detect and degrade transcripts containing premature termination codons. Three 'up-frameshift' proteins, UPF1, UPF2 and UPF3, are essential for this process in organisms ranging from yeast to human. We present a crystal structure at a resolution of 1.95 A of the complex between the interacting domains of human UPF2 and UPF3b, which are, respectively, a MIF4G (middle portion of eIF4G) domain and an RNP domain (ribonucleoprotein-type RNA-binding domain). The protein-protein interface is mediated by highly conserved charged residues in UPF2 and UPF3b and involves the beta-sheet surface of the UPF3b RNP domain, which is generally used by these domains to bind nucleic acids. We show that the UPF3b RNP does not bind RNA, whereas the UPF2 construct and the complex do. Our results advance understanding of the molecular mechanisms underlying the NMD quality control process.
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{{ABSTRACT_PUBMED_15004547}}
==About this Structure==
==About this Structure==
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[[Category: Rna-binding protein]]
[[Category: Rna-binding protein]]
[[Category: Rnp domain]]
[[Category: Rnp domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 22 22:16:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:35:48 2008''

Revision as of 10:35, 27 July 2008

Image:1uw4.png

Template:STRUCTURE 1uw4

THE STRUCTURAL BASIS OF THE INTERACTION BETWEEN NONSENSE MEDIATED DECAY FACTORS UPF2 AND UPF3

Template:ABSTRACT PUBMED 15004547

About this Structure

1UW4 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3., Kadlec J, Izaurralde E, Cusack S, Nat Struct Mol Biol. 2004 Apr;11(4):330-7. Epub 2004 Mar 7. PMID:15004547

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