We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2p22

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2p22.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2p22.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2p22| PDB=2p22 | SCENE= }}
{{STRUCTURE_2p22| PDB=2p22 | SCENE= }}
-
'''Structure of the Yeast ESCRT-I Heterotetramer Core'''
+
===Structure of the Yeast ESCRT-I Heterotetramer Core===
-
==Overview==
+
<!--
-
The endosomal sorting complex required for transport-I (ESCRT-I) complex, which is conserved from yeast to humans, directs the lysosomal degradation of ubiquitinated transmembrane proteins and the budding of the HIV virus. Yeast ESCRT-I contains four subunits, Vps23, Vps28, Vps37, and Mvb12. The crystal structure of the heterotetrameric ESCRT-I complex reveals a highly asymmetric complex of 1:1:1:1 subunit stoichiometry. The core complex is nearly 18 nm long and consists of a headpiece attached to a 13 nm stalk. The stalk is important for cargo sorting by ESCRT-I and is proposed to serve as a spacer regulating the correct disposition of cargo and other ESCRT components. Hydrodynamic constraints and crystallographic structures were used to generate a model of intact ESCRT-I in solution. The results show how ESCRT-I uses a combination of a rigid stalk and flexible tethers to interact with lipids, cargo, and other ESCRT complexes over a span of approximately 25 nm.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17442384}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17442384 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17442384}}
==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Vps28]]
[[Category: Vps28]]
[[Category: Vps37]]
[[Category: Vps37]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 12:10:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:58:45 2008''

Revision as of 10:58, 27 July 2008

Image:2p22.png

Template:STRUCTURE 2p22

Structure of the Yeast ESCRT-I Heterotetramer Core

Template:ABSTRACT PUBMED 17442384

About this Structure

2P22 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer., Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH, Cell. 2007 May 4;129(3):485-98. Epub 2007 Apr 19. PMID:17442384

Page seeded by OCA on Sun Jul 27 13:58:45 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2p22"
Personal tools