This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1r6f

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1r6f.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1r6f.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1r6f| PDB=1r6f | SCENE= }}
{{STRUCTURE_1r6f| PDB=1r6f | SCENE= }}
-
'''The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague'''
+
===The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague===
-
==Overview==
+
<!--
-
The LcrV protein (V-antigen) is a multifunctional virulence factor in Yersinia pestis, the causative agent of plague. LcrV regulates the translocation of cytotoxic effector proteins from the bacterium into the cytosol of mammalian cells via a type III secretion system, possesses antihost activities of its own, and is also an active and passive mediator of resistance to disease. Although a crystal structure of this protein has been actively sought for better understanding of its role in pathogenesis, the wild-type LcrV was found to be recalcitrant to crystallization. We employed a surface entropy reduction mutagenesis strategy to obtain crystals of LcrV that diffract to 2.2 A and determined its structure. The refined model reveals a dumbbell-like molecule with a novel fold that includes an unexpected coiled-coil motif, and provides a detailed three-dimensional roadmap for exploring structure-function relationships in this essential virulence determinant.
+
The line below this paragraph, {{ABSTRACT_PUBMED_14962390}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 14962390 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_14962390}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Waugh, D S.]]
[[Category: Waugh, D S.]]
[[Category: Coiled-coil]]
[[Category: Coiled-coil]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:08:28 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:32:34 2008''

Revision as of 11:32, 27 July 2008

Image:1r6f.png

Template:STRUCTURE 1r6f

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

Template:ABSTRACT PUBMED 14962390

About this Structure

1R6F is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague., Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS, Structure. 2004 Feb;12(2):301-6. PMID:14962390

Page seeded by OCA on Sun Jul 27 14:32:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1r6f"
Personal tools