2au1

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{{STRUCTURE_2au1| PDB=2au1 | SCENE= }}
{{STRUCTURE_2au1| PDB=2au1 | SCENE= }}
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'''Crystal Structure of group A Streptococcus MAC-1 orthorhombic form'''
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===Crystal Structure of group A Streptococcus MAC-1 orthorhombic form===
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==Overview==
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Group A Streptococcus secretes cysteine proteases named Mac-1 and Mac-2 that mediate host immune evasion by targeting both IgG and Fc receptors. Here, we report the crystal structures of Mac-1 and its catalytically inactive C94A mutant in two different crystal forms. Despite the lack of sequence homology, Mac-1 adopts the canonical papain fold. Alanine mutations at the active site confirmed the critical residues involved in a papain-like catalytic mechanism. Mac-1 forms a symmetric dimer in both crystal forms and displays the unique dimer interface among papain superfamily members. Mutations at the dimer interface resulted in a significant reduction in IgG binding and catalysis, suggesting that the dimer contributes to both IgG specificity and enzyme cooperativity. A tunnel observed at the dimer interface constitutes a target for designing potential Mac-1-specific antimicrobial agents. The structures also offer insight into the functional difference between Mac-1 and Mac-2.
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(as it appears on PubMed at http://www.pubmed.gov), where 16472742 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16472742}}
==About this Structure==
==About this Structure==
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[[Category: Sun, P D.]]
[[Category: Sun, P D.]]
[[Category: Mac-1]]
[[Category: Mac-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 19:28:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:36:51 2008''

Revision as of 11:36, 27 July 2008

Image:2au1.png

Template:STRUCTURE 2au1

Crystal Structure of group A Streptococcus MAC-1 orthorhombic form

Template:ABSTRACT PUBMED 16472742

About this Structure

2AU1 is a Single protein structure of sequence from Streptococcus pyogenes mgas5005. Full crystallographic information is available from OCA.

Reference

Crystal structure of group A streptococcus Mac-1: insight into dimer-mediated specificity for recognition of human IgG., Agniswamy J, Nagiec MJ, Liu M, Schuck P, Musser JM, Sun PD, Structure. 2006 Feb;14(2):225-35. PMID:16472742

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