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2b2g

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[[Image:2b2g.gif|left|200px]]
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{{STRUCTURE_2b2g| PDB=2b2g | SCENE= }}
{{STRUCTURE_2b2g| PDB=2b2g | SCENE= }}
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'''MS2 Wild-type RNA stemloop complexed with an N87S mutant MS2 capsid'''
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===MS2 Wild-type RNA stemloop complexed with an N87S mutant MS2 capsid===
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==Overview==
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Sequence-specific interactions between RNA stem-loops and coat protein (CP) subunits play vital roles in the life cycles of the RNA bacteriophages, e.g., by allowing translational repression of their replicase cistrons and tagging their own RNA genomes for encapsidation. The CPs of bacteriophages Qbeta and MS2 each discriminate in favor of their cognate translational operators, even in the presence of closely related operators from other phages in vivo. Discrete mutations within the MS2 CP have been shown to relax this discrimination in vitro. We have determined the structures of eight complexes between such mutants and both MS2 and Qbeta stem-loops with X-ray crystallography. In conjunction with previously determined in vivo repression data, the structures enable us to propose the molecular basis for the discrimination mechanism.
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(as it appears on PubMed at http://www.pubmed.gov), where 16531233 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16531233}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:55:37 2008''

Revision as of 11:55, 27 July 2008

Image:2b2g.png

Template:STRUCTURE 2b2g

MS2 Wild-type RNA stemloop complexed with an N87S mutant MS2 capsid

Template:ABSTRACT PUBMED 16531233

About this Structure

2B2G is a Single protein structure of sequence from Enterobacterio phage ms2. Full crystallographic information is available from OCA.

Reference

Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2., Horn WT, Tars K, Grahn E, Helgstrand C, Baron AJ, Lago H, Adams CJ, Peabody DS, Phillips SE, Stonehouse NJ, Liljas L, Stockley PG, Structure. 2006 Mar;14(3):487-95. PMID:16531233

Page seeded by OCA on Sun Jul 27 14:55:37 2008

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