2bbz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2bbz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2bbz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bbz| PDB=2bbz | SCENE= }}
{{STRUCTURE_2bbz| PDB=2bbz | SCENE= }}
-
'''Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition'''
+
===Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition===
-
==Overview==
+
<!--
-
The death-inducing signaling complex (DISC) comprising Fas, Fas-associated death domain (FADD), and caspase-8/10 is assembled via homotypic associations between death domains (DDs) of Fas and FADD and between death effector domains (DEDs) of FADD and caspase-8/10. Caspase-8/10 and FLICE/caspase-8 inhibitory proteins (FLIPs) that inhibit caspase activation at the DISC level contain tandem DEDs. Here, we report the crystal structure of a viral FLIP, MC159, at 1.2 Angstroms resolution. It reveals a noncanonical fold of DED1, a dumbbell-shaped structure with rigidly associated DEDs and a different mode of interaction in the DD superfamily. Whereas the conserved hydrophobic patch of DED1 interacts with DED2, the corresponding region of DED2 mediates caspase-8 recruitment and contributes to DISC assembly. In contrast, MC159 cooperatively assembles with Fas and FADD via an extensive surface that encompasses the conserved charge triad. This interaction apparently competes with FADD self-association and disrupts higher-order oligomerization required for caspase activation in the DISC.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16364918}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16364918 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16364918}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Zheng, L.]]
[[Category: Zheng, L.]]
[[Category: Death effector domain]]
[[Category: Death effector domain]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 20:05:32 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:24:51 2008''

Revision as of 12:24, 27 July 2008

Image:2bbz.png

Template:STRUCTURE 2bbz

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

Template:ABSTRACT PUBMED 16364918

About this Structure

2BBZ is a Single protein structure of sequence from Molluscum contagiosum virus subtype 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of MC159 reveals molecular mechanism of DISC assembly and FLIP inhibition., Yang JK, Wang L, Zheng L, Wan F, Ahmed M, Lenardo MJ, Wu H, Mol Cell. 2005 Dec 22;20(6):939-49. PMID:16364918

Page seeded by OCA on Sun Jul 27 15:24:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bbz"
Personal tools