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1n11

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[[Image:1n11.gif|left|200px]]
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{{STRUCTURE_1n11| PDB=1n11 | SCENE= }}
{{STRUCTURE_1n11| PDB=1n11 | SCENE= }}
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'''D34 REGION OF HUMAN ANKYRIN-R AND LINKER'''
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===D34 REGION OF HUMAN ANKYRIN-R AND LINKER===
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==Overview==
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Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. The N-terminal, 'membrane-binding' domain of ankyrins contains 24 ANK repeats and mediates most binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. Here we report the crystal structure of a human ankyrinR construct containing ANK repeats 13-24 and a portion of the spectrin-binding domain. The ANK repeats are observed to form a contiguous spiral stack with which the spectrin-binding domain fragment associates as an extended strand. The structural information has been used to construct models of all 24 repeats of the membrane-binding domain as well as the interactions of the repeats with the Cl/HCO(3) anion exchanger and clathrin. These models, together with available binding studies, suggest that ion transporters such as the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
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(as it appears on PubMed at http://www.pubmed.gov), where 12456646 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12456646}}
==About this Structure==
==About this Structure==
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[[Category: Band 3]]
[[Category: Band 3]]
[[Category: Clathrin]]
[[Category: Clathrin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:57:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:44:03 2008''

Revision as of 12:44, 27 July 2008

Image:1n11.png

Template:STRUCTURE 1n11

D34 REGION OF HUMAN ANKYRIN-R AND LINKER

Template:ABSTRACT PUBMED 12456646

About this Structure

1N11 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a 12 ANK repeat stack from human ankyrinR., Michaely P, Tomchick DR, Machius M, Anderson RG, EMBO J. 2002 Dec 2;21(23):6387-96. PMID:12456646

Page seeded by OCA on Sun Jul 27 15:44:03 2008

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