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1n22

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[[Image:1n22.gif|left|200px]]
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{{STRUCTURE_1n22| PDB=1n22 | SCENE= }}
{{STRUCTURE_1n22| PDB=1n22 | SCENE= }}
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'''(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene'''
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===(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene===
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==Overview==
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The x-ray crystal structure of dimeric (+)-bornyl diphosphate synthase, a metal-requiring monoterpene cyclase from Salvia officinalis, is reported at 2.0-A resolution. Each monomer contains two alpha-helical domains: the C-terminal domain catalyzes the cyclization of geranyl diphosphate, orienting and stabilizing multiple reactive carbocation intermediates; the N-terminal domain has no clearly defined function, although its N terminus caps the active site in the C-terminal domain during catalysis. Structures of complexes with aza analogues of substrate and carbocation intermediates, as well as complexes with pyrophosphate and bornyl diphosphate, provide "snapshots" of the terpene cyclization cascade.
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(as it appears on PubMed at http://www.pubmed.gov), where 12432096 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12432096}}
==About this Structure==
==About this Structure==
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[[Category: Wise, M L.]]
[[Category: Wise, M L.]]
[[Category: Terpene synthase fold]]
[[Category: Terpene synthase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:59:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:59:33 2008''

Revision as of 12:59, 27 July 2008

Image:1n22.png

Template:STRUCTURE 1n22

(+)-Bornyl Diphosphate Synthase: Complex with Mg, pyrophosphate, and (4R)-7-aza-7,8-dihydrolimonene

Template:ABSTRACT PUBMED 12432096

About this Structure

1N22 is a Single protein structure of sequence from Salvia officinalis. Full crystallographic information is available from OCA.

Reference

Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase., Whittington DA, Wise ML, Urbansky M, Coates RM, Croteau RB, Christianson DW, Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15375-80. Epub 2002 Nov 13. PMID:12432096

Page seeded by OCA on Sun Jul 27 15:59:33 2008

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